Intermittent Hypoxia Initiated Motor Plasticity in Individuals With Multiple Sclerosis

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS). This intervention with low levels of oxygen is called Acute Intermittent Hypoxia (AIH), the levels of oxygen experienced are similar to breathing the air on a tall mountain, for less than 1 minute at a time. Previous studies have shown that AIH is a safe and effective way to increase strength in persons with MS. Here the investigators aim to look at brain activation and ankle strength before and after AIH to gain a better understanding of how the AIH may improve strength in those persons with MS.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Diagnoses of relapsing form of MS (including relapsing-remitting MS and secondary-progressive MS)

• Expanded Disability Status Scale (EDSS) score of at least 3 and no more than 6.5

• Motor Functional System Scale (FSS) between 2-4

• Relapse free for at least 1 year

• Age ≥ 18 years and ≤ 75 years

• Safe to be scanned based on MRI questionnaire

• Participants using dalfampridine will be eligible if taking the same daily dose for at least 2 months prior to screening

Locations
United States
Illinois
Shirley Ryan AbilityLab
RECRUITING
Chicago
Contact Information
Primary
Alexander Barry, MS, CCRC
abarry@sralab.org
3122381435
Time Frame
Start Date: 2024-04-30
Estimated Completion Date: 2027-01
Participants
Target number of participants: 21
Treatments
Experimental: AIH First
Participants in the AIH First arm will undergo 5 days of Acute Intermittent Hypoxia Interventions. Following the 5 Days of AIH, after a 2-week washout period, this group will then undergo 5 days of Sham AIH Interventions. The procedures are identical to AIH but with 21% oxygen for both breath cycles
Experimental: Sham First
Participants in the Sham First arm will undergo 5 days of Sham-Acute Intermittent Hypoxia Interventions. Following the 5 Days of Sham-AIH, after a 2-week washout period, this group will then undergo 5 days of AIH Interventions. The procedures are identical to Sham-AIH but with 9-10% oxygen for the first breath cycle
Sponsors
Leads: Shirley Ryan AbilityLab
Collaborators: Northwestern University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

This content was sourced from clinicaltrials.gov